Yondelis 1mg Trabactedine Injection

Yondelis Trabactedine Injection Specifications:

Brand Name: Yondelis
Contents: Trabactedine
Manufacturer Johnson & Johnson
Strength: 1mg & 0.25 mg




 Medicines Details  



Trabactedine is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. It is classified as an "alkylating agent." Alkylating agents are most active in the resting phase of the cell. These drugs are cell-cycle non-specific. There are several types of alkylating agents classified according to the substances with which they interfere.


Trabectedin Injection is used to treat liposarcoma, a rare type of cancer that grows in fatty tissues of the body. It is also used to treat leiomyosarcoma, a rare fast-growing type of cancer that grows in many tissues of the body, including fat, muscle, bone, joints, and blood vessels. It is used to treat cancer that has spread to other parts of the body or cannot be treated with surgery.


nausea, vomiting, loss of appetite; diarrhea, constipation; abnormal liver or kidney function tests; headache; or feeling short of breath.

Call your doctor at once if you have:

  • pain, burning, irritation, or skin changes where the injection was given;
  • heart problems--chest pain, fast or pounding heartbeats, shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • breakdown of muscle tissue--unexplained muscle pain, tenderness, or weakness (especially if you also have fever, unusual tiredness, and dark colored urine);
  • liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding, feeling tired or light-headed.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.


Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood cell counts, liver disease (such as active hepatitis), kidney disease, recent/current infections.

This drug may make you tired and weak. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages. Alcohol can increase the risk of liver problems.

Yondelis can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

This medication may damage sperm in men. For both men and women using this medication, Trabactedine may decrease the ability to have children in the future. Consult your doctor for more details.

This medication must not be used during pregnancy. It may harm an unborn baby. If you become pregnant or think you may be pregnant, or if your partner becomes pregnant, tell your doctor right away.

It is unknown if this drug passes into breast milk. Do not breast-feed while using this drug and for 3 months after treatment.

This is not a complete list. Ask your health care provider for more information.


Drug vials should be stored in a refrigerator at 2 to 8 degrees Celsius (36 to 46 Fahrenheit).


Some medications can affect the removal of Yondelis from your body, thereby affecting how this medication works. These drugs include azole antifungals (such as fluconazole, ketoconazole), macrolide antibiotics (such as clarithromycin), HIV drugs (such as ritonavir), rifamycins (such as rifabutin), St. John's wort, and some drugs used to treat seizures (such as carbamazepine, phenobarbital), among others.

This document does not contain all possible interactions. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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