Brand Name : Crizalk
Active Ingredients : Crizotinib
Manufactured by: Pfizer, Inc.
Strength: 250 mg
Packing: Pack of 60 Capsules
Crizotinib is a targeted therapy. It is an oral receptor tyrosine kinase inhibitor. It is a cancer medication that interferes with the growth and spread of cancer cells in the body.
Crizotinib Capsules is used for the treatment of non-small cell lung cancer that is caused by a defect in a gene called ALK (anaplastic lymphoma kinase). The cancer must be (ALK)-positive as indicated by an FDA-approved test. This medicine blocks an enzyme called anaplastic lymphoma kinase (ALK). Some lung cancer cells have an overactive version of ALK. Blocking ALK with crizotinib can stop the cells growing but it only works in cancers with the overactive enzyme. About 1 in 20 people (5%) with non small cell lung cancer (NSCLC) have the overactive ALK enzyme.
nausea, vomiting; diarrhea, constipation; swelling in your hands or feet; tired feeling; or vision problems such as blurred vision, increased sensitivity of your eyes to light, or seeing flashes of light or "floaters."
Call your doctor at once if you have:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Crizalk may cause dizziness, tiredness, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use this medication with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Crizalk may cause vision changes such as blurred vision, flashes of light, floaters in your vision, or sensitivity to light. If this occurs, it usually begins within 1 week after starting this medication. Tell your doctor right away if you develop any of these symptoms.
Serious and sometimes fatal liver problems have occurred in patients taking Crizalk. Contact your doctor right away if you develop dark urine; persistent loss of appetite; right-sided stomach pain; severe or persistent tiredness, nausea, or vomiting; or yellowing of the skin or eyes.
Lab tests, including liver and heart function, blood pressure, blood electrolytes, eye exams, and complete blood cell counts, may be performed while you use Crizalk. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
PREGNANCY and BREAST-FEEDING: Crizalk may cause harm to the fetus. Avoid becoming pregnant while you are taking it and for 90 days after you stop taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking this medication.
This is not a complete list. Ask your health care provider for more information.
Store between 20°C and 25°C (68°F and 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F)
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some medications can affect the removal of Crizotinib from your body, which may affect how it works. Examples include azole antifungals (such as itraconazole), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), drugs for seizures (such as carbamazepine, phenytoin), St. John's wort, among others.